Table 1 Typical membrane proteins screened based on resistance to the membrane inhibitory effect induced by high matrix stiffness

Prelamin-A/C

LMNA

1.44066

1.503553

1.085137

Small nuclear ribonucleoprotein E

SNRPE

1.442228

1.540465

1.354483

Insulin-like growth factor-binding protein 1

IGFBP1

1.934701

2.022608

1.862529

Cytochrome c

CYCS

1.055029

2.020912

1.032612

Rho GTPase-activating protein 17

ARHGAP17

1.460284

1.885713

1.442544

Calcium/calmodulin-dependent protein kinase type II subunit delta

CAMK2D

1.380145

1.73068

1.372204

Bcl-2-binding component 3

BBC3

1.753446

1.876528

1.271211

Lamina-associated polypeptide 2, isoform alpha

TMPO

1.521199

1.408843

1.319708

Keratin, type I cytoskeletal 17

KRT17

1.823483

1.285828

1.145455

Importin subunit alpha-5

KPNA1

1.500398

1.471094

1.256237

Nuclear mitotic apparatus protein 1

NUMA1

1.964777

1.070844

1.026603

Programmed cell death protein 4

PDCD4

1.558858

1.062319

1.008753

Zinc finger HIT domain-containing protein 2

ZNHIT2

2.118072

1.276212

0.873924

Lysine-specific demethylase 2A

KDM2A

1.645833

1.185506

1.064857

Chromodomain-helicase-DNA-binding protein 4

CHD4

1.616529

1.310324

1.129761

Ubiquitin-like domain-containing CTD phosphatase 1

UBLCP1

1.514853

1.189058

1.150809

Importin subunit alpha-3

KPNA4

1.578245

1.115025

1.123152

Complement decay-accelerating factor

CD55

1.724473

1.438625

1.576691

Sodium/myo-inositol cotransporter

SLC5A3

1.615669

1.228817

1.454788

TFIIH basal transcription factor complex helicase XPB subunit

ERCC3

1.526915

1.146046

1.165517

High affinity cationic amino acid transporter 1

SLC7A1

1.774459

1.184333

1.540541

Annexin A2

ANXA2

0.61652

0.899812

0.86238

Pyruvate kinase PKM

PKM

0.58267

0.953339

0.9183

Moesin

MSN

0.592999

0.965812

0.718781

Peptidyl-prolyl cis–trans isomerase A

PPIA

0.62565

0.790193

0.735385

Na( +)/H( +) exchange regulatory cofactor NHE-RF1

SLC9A3R1

0.620426

0.888193

0.711522

40S ribosomal protein SA

RPSA

0.587755

0.767195

0.699355

Ubiquitin-40S ribosomal protein S27a

RPS27A

0.651907

0.823816

0.771223

Destrin

DSTN

0.534129

0.845319

0.834041

Cofilin-1

CFL1

0.430929

1.067309

0.864193

LIM and SH3 domain protein 1

LASP1

0.630703

0.832025

0.796359

Fascin

FSCN1

0.665624

0.875154

0.806212

General vesicular transport factor p115

USO1

0.633543

1.006682

0.777284

Cysteine and glycine-rich protein 1

CSRP1

0.630921

1.09839

0.787614

Calponin-2

CNN2

0.651804

0.87804

0.813255

Plasminogen activator inhibitor 1 RNA-binding protein

SERBP1

0.622013

0.906532

0.760247

Protein S100-A6

S100A6

0.607469

1.085248

0.689778

40S ribosomal protein S20

RPS20

0.648542

1.040342

0.885948

Protein S100-A10

S100A10

0.53718

1.349493

0.94674

Fatty acid-binding protein, epidermal

FABP5

0.552082

0.764246

0.680111

Cdc42 effector protein 4

CDC42EP4

0.569404

0.9141

0.787523

Methionine aminopeptidase 2

METAP2

0.523168

1.185742

0.885365

Clustered mitochondria protein homolog

CLUH

0.638349

0.760548

0.749095

Programmed cell death protein 5

PDCD5

0.561837

0.804717

0.652728

Tax1-binding protein 3

TAX1BP3

0.637478

1.147379

0.826159

28S ribosomal protein S21, mitochondrial

MRPS21

0.586635

0.711005

0.609355

Apoptosis-associated speck-like protein containing a CARD

PYCARD

0.604483

0.765976

0.701165

Early endosome antigen 1

EEA1

0.572098

0.869641

0.785589

Tetratricopeptide repeat protein 17

TTC17

0.629422

0.783653

0.776334

Exocyst complex component 5

EXOC5

0.628536

0.772019

0.733332

Thioredoxin domain-containing protein 17

TXNDC17

0.550895

0.739947

0.711344

Malignant T-cell-amplified sequence 1

MCTS1

0.593491

1.018201

0.726474

Keratin, type II cuticular Hb6

KRT86

0.569451

0.607246

0.570316

Myotrophin

MTPN

0.642847

1.312341

0.948826

Thymosin beta-10

TMSB10

0.570746

1.245873

0.678481

Interleukin-1 alpha

IL1A

0.615046

0.695885

0.661868

Sulfiredoxin-1

SRXN1

0.58674

0.637876

0.590507

SH3 domain-binding glutamic acid-rich-like protein 3

SH3BGRL3

0.476877

0.627616

0.619659

Filamin-A

FLNA

0.624602

0.843308

0.97049

Glucose-6-phosphate 1-dehydrogenase

G6PD

0.616705

0.800959

0.938911

Myosin-9

MYH9

0.523293

0.747035

0.853047

Fatty acid synthase

FASN

0.582805

0.659283

0.722716

Elongation factor 2

EEF2

0.599412

0.870375

0.918953

Talin-1

TLN1

0.600162

0.809829

0.902139

40S ribosomal protein S21

RPS21

0.603461

0.922122

0.928002

Transgelin-2

TAGLN2

0.461376

0.84302

0.886943

Cystatin-B

CSTB

0.478538

0.692575

0.769809

Flavin reductase (NADPH)

BLVRB

0.65842

0.72311

0.734823

Nucleosome assembly protein 1-like 1

NAP1L1

0.457118

0.811807

0.891115

Golgin subfamily A member 1

GOLGA1

0.620774

0.686481

0.714003

Programmed cell death protein 6

PDCD6

0.646062

0.745869

0.84697

Hepatocyte growth factor-regulated tyrosine kinase substrate

HGS

0.633505

0.901127

1.041291

Ubiquitin-conjugating enzyme E2 variant 1

UBE2V1

0.615346

0.864989

0.933444

Exocyst complex component 6

EXOC6

0.652659

0.671117

0.719448

Macrophage migration inhibitory factor

MIF

0.6369

0.926661

0.927719

Exocyst complex component 2

EXOC2

0.522173

0.639032

0.69052

cAMP-dependent protein kinase type I-alpha regulatory subunit

PRKAR1A

0.62013

0.626398

0.744376

Exocyst complex component 1

EXOC1

0.577106

0.684352

0.72695

Nucleosome assembly protein 1-like 4

NAP1L4

0.613517

0.673389

0.839352

Alanine–tRNA ligase, cytoplasmic

AARS

0.563899

0.720974

0.853792

E3 ubiquitin-protein ligase MARCH6

6-Mar

0.637299

0.650759

0.83165

Histone H3.1

HIST1H3A

0.663002

0.851717

1.037266

Sequestosome-1

SQSTM1

0.573854

0.57978

0.588272

Peptidyl-prolyl cis–trans isomerase FKBP1A

FKBP1A

0.419217

0.426265

0.572027

Tubulin alpha chain-like 3

TUBAL3

0.75047

0.593122

0.753641

28S ribosomal protein S11, mitochondrial

MRPS11

0.647251

0.637203

0.669923

39S ribosomal protein L14, mitochondrial

MRPL14

0.724559

0.615447

0.740257

Protein phosphatase PTC7 homolog

PPTC7

0.760775

0.642389

0.774724

Toll-interacting protein

TOLLIP

0.66985

0.656658

0.762507

Thrombospondin-1

THBS1

0.432559

0.40842

0.580485

Spondin-1

SPON1

0.607419

0.383333

0.834185

Midkine

MDK

0.624462

0.609669

0.855459

Tumor necrosis factor receptor superfamily member 1A

TNFRSF1A

0.691871

0.624775

0.729306

Serpin B7

SERPINB7

0.407513

0.343795

0.460286